Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells

Beta cells from nondiabetic mice transfer secretory vesicles to phagocytic cells. The passage was shown in culture studies where the transfer was probed with CD4 T cells reactive to insulin peptides. Two sets of vesicles were transferred, one containing insulin and another containing catabolites of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Vomund, Anthony N., Zinselmeyer, Bernd H., Hughes, Jing, Calderon, Boris, Valderrama, Carolina, Ferris, Stephen T., Wan, Xiaoxiao, Kanekura, Kohsuke, Carrero, Javier A., Urano, Fumihiko, Unanue, Emil R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603448/
https://ncbi.nlm.nih.gov/pubmed/26324934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1515954112
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