MiR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells

MiR-21 is upregulated in hepatocellular carcinoma and intrahepatic cholangiocarcinoma where it is associated with poor prognosis. Here we offer preclinical evidence that miR-21 offers a therapeutic and chemopreventive target in these liver cancers. In mice with hepatic deletion of Pten, anti-miR-21...

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Vydáno v:Cancer Res
Hlavní autoři: Zhang, Jing, Jiao, Jingjing, Cermelli, Silvia, Muir, Kyle, Jung, Kwang Hwa, Zou, Ruhai, Rashid, Asif, Gagea, Mihai, Zabludoff, Sonya, Kalluri, Raghu, Beretta, Laura
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603420/
https://ncbi.nlm.nih.gov/pubmed/25769721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1254
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