Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

Hallmarks of cancer, including rapid growth and aneuploidy, can result in non-oncogene addiction to the proteostasis network that can be exploited clinically. The defining example is the exquisite sensitivity of multiple myeloma (MM) to 20S proteasome inhibitors, such as carfilzomib. However, MM pat...

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Bibliographic Details
Published in:eLife
Main Authors: Acosta-Alvear, Diego, Cho, Min Y, Wild, Thomas, Buchholz, Tonia J, Lerner, Alana G, Simakova, Olga, Hahn, Jamie, Korde, Neha, Landgren, Ola, Maric, Irina, Choudhary, Chunaram, Walter, Peter, Weissman, Jonathan S, Kampmann, Martin
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602331/
https://ncbi.nlm.nih.gov/pubmed/26327694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08153
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