Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

Hallmarks of cancer, including rapid growth and aneuploidy, can result in non-oncogene addiction to the proteostasis network that can be exploited clinically. The defining example is the exquisite sensitivity of multiple myeloma (MM) to 20S proteasome inhibitors, such as carfilzomib. However, MM pat...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:eLife
Autores principales: Acosta-Alvear, Diego, Cho, Min Y, Wild, Thomas, Buchholz, Tonia J, Lerner, Alana G, Simakova, Olga, Hahn, Jamie, Korde, Neha, Landgren, Ola, Maric, Irina, Choudhary, Chunaram, Walter, Peter, Weissman, Jonathan S, Kampmann, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602331/
https://ncbi.nlm.nih.gov/pubmed/26327694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08153
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares