Transcriptomic Signatures of Auger Electron Radioimmunotherapy Using Nuclear Targeting (111)In-Trastuzumab for Potential Combination Therapies

(111)In-labeled trastuzumab modified with nuclear localizing signal (NLS) peptides ((111)In-trastuzumab-NLS) efficiently delivers an Auger electron (AE) emitter (111)In into the cell nucleus and is thus a promising radiopharmaceutical in AE radioimmunotherapy (AE-RIT) for targeted killing of HER2-po...

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Detalhes bibliográficos
Publicado no:Cancer Biother Radiopharm
Main Authors: Li, Huizi Keiko, Morokoshi, Yukie, Daino, Kazuhiro, Furukawa, Takako, Kamada, Tadashi, Saga, Tsuneo, Hasegawa, Sumitaka
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601633/
https://ncbi.nlm.nih.gov/pubmed/26447839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cbr.2015.1882
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