Splicing changes in SMA mouse motoneurons and SMN-depleted neuroblastoma cells: Evidence for involvement of splicing regulatory proteins

Spinal Muscular Atrophy (SMA) is caused by deletions or mutations in the Survival Motor Neuron 1 (SMN1) gene. The second gene copy, SMN2, produces some, but not enough, functional SMN protein. SMN is essential to assemble small nuclear ribonucleoproteins (snRNPs) that form the spliceosome. However,...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Huo, Qing, Kayikci, Melis, Odermatt, Philipp, Meyer, Kathrin, Michels, Olivia, Saxena, Smita, Ule, Jernej, Schümperli, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601534/
https://ncbi.nlm.nih.gov/pubmed/25692239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2014.996494
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