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Specific binding of eukaryotic ORC to DNA replication origins depends on highly conserved basic residues
In eukaryotes, the origin recognition complex (ORC) heterohexamer preferentially binds replication origins to trigger initiation of DNA replication. Crystallographic studies using eubacterial and archaeal ORC orthologs suggested that eukaryotic ORC may bind to origin DNA via putative winged-helix DN...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4601075/ https://ncbi.nlm.nih.gov/pubmed/26456755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14929 |
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