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The Arg Fingers of Key DnaA Protomers Are Oriented Inward within the Replication Origin oriC and Stimulate DnaA Subcomplexes in the Initiation Complex

ATP-DnaA binds to multiple DnaA boxes in the Escherichia coli replication origin (oriC) and forms left-half and right-half subcomplexes that promote DNA unwinding and DnaB helicase loading. DnaA forms homo-oligomers in a head-to-tail manner via interactions between the bound ATP and Arg-285 of the a...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Noguchi, Yasunori, Sakiyama, Yukari, Kawakami, Hironori, Katayama, Tsutomu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536437/
https://ncbi.nlm.nih.gov/pubmed/26126826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662601
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