Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors

[Image: see text] Antibacterials with a novel mechanism of action offer a great opportunity to combat widespread antimicrobial resistance. Bacterial DNA Gyrase is a clinically validated target. Through physiochemical property optimization of a pyrazolopyridone hit, a novel class of GyrB inhibitors w...

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Publicado en:ACS Med Chem Lett
Autores principales: Zhang, Jing, Yang, Qingyi, Romero, Jan Antoinette C., Cross, Jason, Wang, Bin, Poutsiaka, Katherine M., Epie, Felix, Bevan, Douglas, Wu, Yuchuan, Moy, Terence, Daniel, Anu, Chamberlain, Brian, Carter, Nicole, Shotwell, Joseph, Arya, Anu, Kumar, Vipul, Silverman, Jared, Nguyen, Kien, Metcalf, Chester A., Ryan, Dominic, Lippa, Blaise, Dolle, Roland E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2015
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601062/
https://ncbi.nlm.nih.gov/pubmed/26487916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00266
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