Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors

[Image: see text] Antibacterials with a novel mechanism of action offer a great opportunity to combat widespread antimicrobial resistance. Bacterial DNA Gyrase is a clinically validated target. Through physiochemical property optimization of a pyrazolopyridone hit, a novel class of GyrB inhibitors w...

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Опубликовано в: :ACS Med Chem Lett
Главные авторы: Zhang, Jing, Yang, Qingyi, Romero, Jan Antoinette C., Cross, Jason, Wang, Bin, Poutsiaka, Katherine M., Epie, Felix, Bevan, Douglas, Wu, Yuchuan, Moy, Terence, Daniel, Anu, Chamberlain, Brian, Carter, Nicole, Shotwell, Joseph, Arya, Anu, Kumar, Vipul, Silverman, Jared, Nguyen, Kien, Metcalf, Chester A., Ryan, Dominic, Lippa, Blaise, Dolle, Roland E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2015
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601062/
https://ncbi.nlm.nih.gov/pubmed/26487916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00266
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