Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors

[Image: see text] Antibacterials with a novel mechanism of action offer a great opportunity to combat widespread antimicrobial resistance. Bacterial DNA Gyrase is a clinically validated target. Through physiochemical property optimization of a pyrazolopyridone hit, a novel class of GyrB inhibitors w...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Zhang, Jing, Yang, Qingyi, Romero, Jan Antoinette C., Cross, Jason, Wang, Bin, Poutsiaka, Katherine M., Epie, Felix, Bevan, Douglas, Wu, Yuchuan, Moy, Terence, Daniel, Anu, Chamberlain, Brian, Carter, Nicole, Shotwell, Joseph, Arya, Anu, Kumar, Vipul, Silverman, Jared, Nguyen, Kien, Metcalf, Chester A., Ryan, Dominic, Lippa, Blaise, Dolle, Roland E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601062/
https://ncbi.nlm.nih.gov/pubmed/26487916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00266
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