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A Mechanistic Collective Cell Model for Epithelial Colony Growth and Contact Inhibition

We present a mechanistic hybrid continuum-discrete model to simulate the dynamics of epithelial cell colonies. Collective cell dynamics are modeled using continuum equations that capture plastic, viscoelastic, and elastic deformations in the clusters while providing single-cell resolution. The conti...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Aland, Sebastian, Hatzikirou, Haralambos, Lowengrub, John, Voigt, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601048/
https://ncbi.nlm.nih.gov/pubmed/26445436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.08.003
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