The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

The mitochondrial permeability transition (PT) is a permeability increase of the inner mitochondrial membrane mediated by a channel, the permeability transition pore (PTP). After a brief historical introduction, we cover the key regulatory features of the PTP and provide a critical assessment of put...

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Veröffentlicht in:Physiol Rev
Hauptverfasser: Bernardi, Paolo, Rasola, Andrea, Forte, Michael, Lippe, Giovanna
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600949/
https://ncbi.nlm.nih.gov/pubmed/26269524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physrev.00001.2015
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