Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI

Drug induced liver injury (DILI) is an idiosyncratic adverse drug reaction leading to severe liver damage. Kupffer cells (KC) sense hepatic tissue stress/damage and therefore could be a tool for the estimation of consequent effects associated with DILI. Aim of the present study was to establish a hu...

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Publicado en:Mediators Inflamm
Main Authors: Kegel, Victoria, Pfeiffer, Elisa, Burkhardt, Britta, Liu, Jia L., Zeilinger, Katrin, Nüssler, Andreas K., Seehofer, Daniel, Damm, Georg
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600928/
https://ncbi.nlm.nih.gov/pubmed/26491234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/640631
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