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Postmitotic Expression of SOD1(G93A) Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation

To determine the role of mutant SOD1 gene (SOD1(G93A)) on muscle cell differentiation, we derived C2C12 muscle cell lines carrying a stably transfected SOD1(G93A) gene under the control of a myosin light chain (MLC) promoter-enhancer cassette. Expression of MLC/SOD1(G93A) in C2C12 cells resulted in...

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Publicat a:Mediators Inflamm
Autors principals: Martini, Martina, Dobrowolny, Gabriella, Aucello, Michela, Musarò, Antonio
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600922/
https://ncbi.nlm.nih.gov/pubmed/26491230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/537853
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