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α-Methyl Acyl CoA Racemase Provides Mycobacterium tuberculosis Catabolic Access to Cholesterol Esters
Metabolism of cholesterol by Mycobacterium tuberculosis (Mtb) contributes to its pathogenesis. We show that ChsE4-ChsE5 (Rv3504/Rv3505) specifically catalyzes dehydrogenation of the (25S)-3-oxo-cholest-4-en-26-oyl CoA diastereomer in cholesterol side chain β-oxidation. Thus a dichotomy between the s...
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| Publicado en: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4600597/ https://ncbi.nlm.nih.gov/pubmed/26348625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00911 |
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