Blocking of SMAD4 expression by shRNA effectively inhibits fibrogenesis of human hepatic stellate cells

AIM: In this study, to clarify the SMAD4 blocking impact on fibrosis process, we investigated its down-regulation by shRNA on activated human LX-2 cell, in vitro. BACKGROUND: Liver fibrosis is a critical consequence of chronic damage to the liver that can progress toward advanced diseases, liver cir...

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Bibliografske podrobnosti
izdano v:Gastroenterol Hepatol Bed Bench
Main Authors: Khanizadeh, Sayyad, Ravanshad, Mehrdad, Hosseini, SeyedYounes, Davoodian, Parivash, Nejati Zadeh, Azim, Sarvari, Jamal
Format: Artigo
Jezik:Inglês
Izdano: Shaheed Beheshti University of Medical Sciences 2015
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600516/
https://ncbi.nlm.nih.gov/pubmed/26468346
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