Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis

BACKGROUND: Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim of the study was to describethe genome wide DNA methylation changes in hip and knee OA and identify novel genes and pathwaysinvolved in OA by comparing the DNA methylome of the hip and knee osteoarthritic cart...

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Detalhes bibliográficos
Publicado no:BMC Musculoskelet Disord
Main Authors: Aref-Eshghi, Erfan, Zhang, Yuhua, Liu, Ming, Harper, Patricia E., Martin, Glynn, Furey, Andrew, Green, Roger, Sun, Guang, Rahman, Proton, Zhai, Guangju
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600269/
https://ncbi.nlm.nih.gov/pubmed/26453558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-015-0745-5
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