Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

BACKGROUND: The oncogenic transcription factor MYC is pathologically activated in many human malignancies. A paradigm for MYC dysregulation is offered by Burkitt lymphoma, where chromosomal translocations leading to Immunoglobulin gene-MYC fusion are the crucial initiating oncogenic events. However,...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: De Falco, Giulia, Ambrosio, Maria Raffaella, Fuligni, Fabio, Onnis, Anna, Bellan, Cristiana, Rocca, Bruno Jim, Navari, Mohsen, Etebari, Maryam, Mundo, Lucia, Gazaneo, Sara, Facchetti, Fabio, Pileri, Stefano A., Leoncini, Lorenzo, Piccaluga, Pier Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600215/
https://ncbi.nlm.nih.gov/pubmed/26453442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1661-7
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