TCR signaling intensity controls CD8(+) T cell responsiveness to TGF-β

DGK-ζ is a negative regulator of TCR signaling that causes degradation of the second messenger DAG, terminating DAG-mediated activation of Ras and PKCθ. Cytotoxic T cells deficient in DGK-ζ demonstrate enhanced effector functions in vitro and antitumor activity in vivo, perhaps because of insensitiv...

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Vydáno v:J Leukoc Biol
Hlavní autoři: Arumugam, Vidhyalakshmi, Bluemn, Theresa, Wesley, Erin, Schmidt, Amanda M., Kambayashi, Taku, Malarkannan, Subramaniam, Riese, Matthew J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Leukocyte Biology 2015
Témata:
Spotlight on Leading Edge Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600064/
https://ncbi.nlm.nih.gov/pubmed/26153417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2HIMA1214-578R
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