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TCR signaling intensity controls CD8(+) T cell responsiveness to TGF-β
DGK-ζ is a negative regulator of TCR signaling that causes degradation of the second messenger DAG, terminating DAG-mediated activation of Ras and PKCθ. Cytotoxic T cells deficient in DGK-ζ demonstrate enhanced effector functions in vitro and antitumor activity in vivo, perhaps because of insensitiv...
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| Publicado no: | J Leukoc Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Leukocyte Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4600064/ https://ncbi.nlm.nih.gov/pubmed/26153417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.2HIMA1214-578R |
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