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Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality
Synthetic lethality is a genetic interaction wherein two otherwise nonessential genes cause cellular inviability when knocked out simultaneously. Drugs can mimic genetic knock-out effects; therefore, our understanding of promiscuous drugs, polypharmacology-related adverse drug reactions, and multi-d...
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| Publicat a: | PLoS Comput Biol |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4599967/ https://ncbi.nlm.nih.gov/pubmed/26451775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004506 |
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