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Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality
Synthetic lethality is a genetic interaction wherein two otherwise nonessential genes cause cellular inviability when knocked out simultaneously. Drugs can mimic genetic knock-out effects; therefore, our understanding of promiscuous drugs, polypharmacology-related adverse drug reactions, and multi-d...
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| Publicado no: | PLoS Comput Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4599967/ https://ncbi.nlm.nih.gov/pubmed/26451775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004506 |
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