ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate

In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, we performed genome-wide shRNA screens under hypoxi...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Keenan, Melissa M., Liu, Beiyu, Tang, Xiaohu, Wu, Jianli, Cyr, Derek, Stevens, Robert D., Ilkayeva, Olga, Huang, Zhiqing, Tollini, Laura A., Murphy, Susan K., Lucas, Joseph, Muoio, Deborah M., Kim, So Young, Chi, Jen-Tsan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599891/
https://ncbi.nlm.nih.gov/pubmed/26452058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005599
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