Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways

Klotho transgenic mice exhibit resistance to oxidative stress as measured by their urinal levels of 8-hydroxy-2-deoxyguanosine, albeit this anti-oxidant defense mechanism has not been locally investigated in the brain. Here, we tested the hypothesis that the reactive oxygen species (ROS)-sensitive a...

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Publicado en:PLoS One
Autores principales: Brobey, Reynolds K., German, Dwight, Sonsalla, Patricia K., Gurnani, Prem, Pastor, Johanne, Hsieh, C-C, Papaconstantinou, John, Foster, Philip P., Kuro-o, Makoto, Rosenblatt, Kevin P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599800/
https://ncbi.nlm.nih.gov/pubmed/26452228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139914
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