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Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG–PLA micelle
To improve the pharmacokinetics and stability of recombinant human erythropoietin (rhEPO), rhEPO was successfully formulated into poly(ethylene glycol)–poly(d,l-lactide) (PEG–PLA) di-block copolymeric micelles at diameters ranging from 60 to 200 nm with narrow polydispersity indices (PDIs; PDI <...
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| Veröffentlicht in: | Int J Nanomedicine |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Dove Medical Press
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4599715/ https://ncbi.nlm.nih.gov/pubmed/23293515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S38648 |
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