Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome

BACKGROUND: Interleukin (IL)-1β, IL-18, and downstream IL-6 are key inflammatory cytokines in the pathogenesis of coronary artery disease. Colchicine is believed to block the NLRP3 inflammasome, a cytosolic complex responsible for the production of IL-1β and IL-18. In vivo effects of colchicine on c...

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Publicat a:J Am Heart Assoc
Autors principals: Martínez, Gonzalo J, Robertson, Stacy, Barraclough, Jennifer, Xia, Qiong, Mallat, Ziad, Bursill, Christina, Celermajer, David S, Patel, Sanjay
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599469/
https://ncbi.nlm.nih.gov/pubmed/26304941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002128
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