Hypoxic Niche-Mediated Regeneration of Hematopoiesis in the Engraftment Window Is Dominantly Affected by Oxygen Tension in the Milieu

The bone marrow (BM) microenvironment or the hematopoietic stem cell (HSC) niche is normally hypoxic, which maintains HSC quiescence. Paradoxically, transplanted HSCs rapidly proliferate in this niche. Pretransplant myelosuppression results in a substantial rise in oxygen levels in the marrow microe...

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Detalhes bibliográficos
Publicado no:Stem Cells Dev
Main Authors: Moirangthem, Ranjita Devi, Singh, Shweta, Adsul, Ashwini, Jalnapurkar, Sapana, Limaye, Lalita, Kale, Vaijayanti P.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599134/
https://ncbi.nlm.nih.gov/pubmed/26107807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2015.0112
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