Hypoxic Niche-Mediated Regeneration of Hematopoiesis in the Engraftment Window Is Dominantly Affected by Oxygen Tension in the Milieu

The bone marrow (BM) microenvironment or the hematopoietic stem cell (HSC) niche is normally hypoxic, which maintains HSC quiescence. Paradoxically, transplanted HSCs rapidly proliferate in this niche. Pretransplant myelosuppression results in a substantial rise in oxygen levels in the marrow microe...

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Gepubliceerd in:Stem Cells Dev
Hoofdauteurs: Moirangthem, Ranjita Devi, Singh, Shweta, Adsul, Ashwini, Jalnapurkar, Sapana, Limaye, Lalita, Kale, Vaijayanti P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Mary Ann Liebert, Inc. 2015
Onderwerpen:
Original Research Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599134/
https://ncbi.nlm.nih.gov/pubmed/26107807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2015.0112
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