Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION

Inflammation is a key instigator of the immune responses that drive atherosclerosis and allograft rejection. IL-1α, a powerful cytokine that activates both innate and adaptive immunity, induces vessel inflammation after release from necrotic vascular smooth muscle cells (VSMCs). Similarly, IL-1α rel...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Burzynski, Laura C., Humphry, Melanie, Bennett, Martin R., Clarke, Murray C. H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599021/
https://ncbi.nlm.nih.gov/pubmed/26324711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.667915
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