Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen

Prostate-associated gene 4 (PAGE4) is an intrinsically disordered cancer/testis antigen that is up-regulated in the fetal and diseased human prostate. Knocking down PAGE4 expression results in cell death, whereas its overexpression leads to a growth advantage of prostate cancer cells (Zeng, Y., He,...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: He, Yanan, Chen, Yihong, Mooney, Steven M., Rajagopalan, Krithika, Bhargava, Ajay, Sacho, Elizabeth, Weninger, Keith, Bryan, Philip N., Kulkarni, Prakash, Orban, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599013/
https://ncbi.nlm.nih.gov/pubmed/26242913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658583
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