Selective Irreversible Inhibition of Neuronal and Inducible Nitric-oxide Synthase in the Combined Presence of Hydrogen Sulfide and Nitric Oxide

Citrulline formation by both human neuronal nitric-oxide synthase (nNOS) and mouse macrophage inducible NOS was inhibited by the hydrogen sulfide (H(2)S) donor Na(2)S with IC(50) values of ∼2.4·10(−5) and ∼7.9·10(−5) m, respectively, whereas human endothelial NOS was hardly affected at all. Inhibiti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Heine, Christian L., Schmidt, Renate, Geckl, Kerstin, Schrammel, Astrid, Gesslbauer, Bernd, Schmidt, Kurt, Mayer, Bernd, Gorren, Antonius C. F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Enzymology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599001/
https://ncbi.nlm.nih.gov/pubmed/26296888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.660316
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