Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines

BACKGROUND: Trastuzumab is a humanized monoclonal antibody (mAb) currently used for the treatment of breast cancer (BC) patients with HER-2 overexpressing tumor subtype. Previous data reported the involvement of FcγRIIIA/IIA gene polymorphisms and/or antibody-dependent cellular cytotoxicity (ADCC) i...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Transl Med
Päätekijät: Boero, Silvia, Morabito, Anna, Banelli, Barbara, Cardinali, Barbara, Dozin, Beatrice, Lunardi, Gianluigi, Piccioli, Patrizia, Lastraioli, Sonia, Carosio, Roberta, Salvi, Sandra, Levaggi, Alessia, Poggio, Francesca, D’Alonzo, Alessia, Romani, Massimo, Del Mastro, Lucia, Poggi, Alessandro, Pistillo, Maria Pia
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2015
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598965/
https://ncbi.nlm.nih.gov/pubmed/26450443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0680-0
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