Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells

The RNA-binding protein tristetraprolin (TTP) promotes rapid decay of mRNAs bearing 3' UTR AU-rich elements (ARE). In many cancer types, loss of TTP expression is observed allowing for stabilization of ARE-mRNAs and their pathologic overexpression. Here we demonstrate that histone deacetylase (...

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Pubblicato in:Biomolecules
Autori principali: Sobolewski, Cyril, Sanduja, Sandhya, Blanco, Fernando F., Hu, Liangyan, Dixon, Dan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598787/
https://ncbi.nlm.nih.gov/pubmed/26343742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom5032035
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