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Characterization of Endoribonuclease Active Site of Human Apurinic/Apyrimidinic Endonuclease 1
Apurinic/apyrimidinic endonuclease 1 (APE1) is the major mammalian enzyme in DNA base excision repair that cleaves the DNA phosphodiester backbone immediately 5′ to abasic sites. Recently, we identified APE1 as an endoribonuclease that cleaves a specific coding region of c-myc mRNA in vitro, regulat...
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| Published in: | J Mol Biol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598366/ https://ncbi.nlm.nih.gov/pubmed/21762700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.06.050 |
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