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Characterization of Endoribonuclease Active Site of Human Apurinic/Apyrimidinic Endonuclease 1

Apurinic/apyrimidinic endonuclease 1 (APE1) is the major mammalian enzyme in DNA base excision repair that cleaves the DNA phosphodiester backbone immediately 5′ to abasic sites. Recently, we identified APE1 as an endoribonuclease that cleaves a specific coding region of c-myc mRNA in vitro, regulat...

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Podrobná bibliografie
Vydáno v:J Mol Biol
Hlavní autoři: Kim, Wan-Cheol, Berquist, Brian R., Chohan, Manbir, Uy, Christopher, Wilson, David M., Lee, Chow H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598366/
https://ncbi.nlm.nih.gov/pubmed/21762700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.06.050
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