The association between sterilizing activity and drug distribution into tuberculosis lesions

Finding new treatment-shortening antibiotics to improve cure rates and curb the alarming emergence of drug resistance is the major objective of tuberculosis (TB) drug development. Using a MALDI mass spectrometry imaging suite in a biosafety containment facility, we show that the key sterilizing drug...

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Pubblicato in:Nat Med
Autori principali: Prideaux, Brendan, Via, Laura E., Zimmerman, Matthew D., Eum, Seokyong, Sarathy, Jansy, O’Brien, Paul, Chen, Chao, Kaya, Firat, Weiner, Danielle M., Chen, Pei-Yu, Song, Taeksun, Lee, Myungsun, Shim, TaeSun, Cho, Jeong Su, Kim, Wooshik, Cho, Sang Nae, Olivier, Kenneth N., Barry, Clifton E., Dartois, Véronique
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598290/
https://ncbi.nlm.nih.gov/pubmed/26343800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3937
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