Treatment with 5-Aza-2'-Deoxycytidine Induces Expression of NY-ESO-1 and Facilitates Cytotoxic T Lymphocyte-Mediated Tumor Cell Killing

BACKGROUND: NY-ESO-1 belongs to the cancer/testis antigen (CTA) family and represents an attractive target for cancer immunotherapy. Its expression is induced in a variety of solid tumors via DNA demethylation of the promoter of CpG islands. However, NY-ESO-1 expression is usually very low or absent...

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Udgivet i:PLoS One
Main Authors: Klar, Agnes S., Gopinadh, Jakka, Kleber, Sascha, Wadle, Andreas, Renner, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598131/
https://ncbi.nlm.nih.gov/pubmed/26447882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139221
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