Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence

OBJECTIVE: Patients with acromegaly exhibit reduced life expectancy and increased prevalence of age-related diseases, such as diabetes, hypertension, and cardiovascular disease. However, the underlying mechanism has not been fully elucidated. Telomere shortening is reportedly associated with reduced...

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Vydáno v:PLoS One
Hlavní autoři: Matsumoto, Ryusaku, Fukuoka, Hidenori, Iguchi, Genzo, Odake, Yukiko, Yoshida, Kenichi, Bando, Hironori, Suda, Kentaro, Nishizawa, Hitoshi, Takahashi, Michiko, Yamada, Shozo, Ogawa, Wataru, Takahashi, Yutaka
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598111/
https://ncbi.nlm.nih.gov/pubmed/26448623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140189
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