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Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution

Functional diversification of motor neurons has occurred in order to selectively control the movements of different body parts including head, trunk and limbs. Here we report that transcription of Isl1, a major gene necessary for motor neuron identity, is controlled by two enhancers, CREST1 (E1) and...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Kim, Namhee, Park, Chungoo, Jeong, Yongsu, Song, Mi-Ryoung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598079/
https://ncbi.nlm.nih.gov/pubmed/26447474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005560
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