Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses

Cystic fibrosis lung disease is characterized by chronic airway infections with the opportunistic pathogen Pseudomonas aeruginosa and severe neutrophilic pulmonary inflammation. P. aeruginosa undergoes extensive genetic adaptation to the cystic fibrosis (CF) lung environment, and adaptive mutations...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: LaFayette, Shantelle L., Houle, Daniel, Beaudoin, Trevor, Wojewodka, Gabriella, Radzioch, Danuta, Hoffman, Lucas R., Burns, Jane L., Dandekar, Ajai A., Smalley, Nicole E., Chandler, Josephine R., Zlosnik, James E., Speert, David P., Bernier, Joanie, Matouk, Elias, Brochiero, Emmanuelle, Rousseau, Simon, Nguyen, Dao
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597794/
https://ncbi.nlm.nih.gov/pubmed/26457326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500199
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