Fitness Assays Reveal Incomplete Functional Redundancy of the HoxA1 and HoxB1 Paralogs of Mice

Gene targeting techniques have led to the phenotypic characterization of numerous genes; however, many genes show minimal to no phenotypic consequences when disrupted, despite many having highly conserved sequences. The standard explanation for these findings is functional redundancy. A competing hy...

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Veröffentlicht in:Genetics
Hauptverfasser: Ruff, James S., Saffarini, Raed B., Ramoz, Leda L., Morrison, Linda C., Baker, Shambralyn, Laverty, Sean M., Tvrdik, Petr, Potts, Wayne K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Genetics Society of America 2015
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Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596679/
https://ncbi.nlm.nih.gov/pubmed/26447130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.178079
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