Mouse fitness measures reveal incomplete functional redundancy of Hox paralogous group 1 proteins

Here we assess the fitness consequences of the replacement of the Hoxa1 coding region with its paralog Hoxb1 in mice (Mus musculus) residing in semi-natural enclosures. Previously, this Hoxa1(B1) swap was reported as resulting in no discernible embryonic or physiological phenotype (i.e., functionall...

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Publicat a:PLoS One
Autors principals: Ruff, James S., Saffarini, Raed B., Ramoz, Leda L., Morrison, Linda C., Baker, Shambralyn, Laverty, Sean M., Tvrdik, Petr, Capecchi, Mario R., Potts, Wayne K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381901/
https://ncbi.nlm.nih.gov/pubmed/28380068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174975
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