Interleukin-1 Antagonist Anakinra in Amyotrophic Lateral Sclerosis—A Pilot Study

Preclinical studies show that blocking Interleukin–1 (IL–1) retards the progression of Amyotrophic Lateral Sclerosis (ALS). We assessed the safety of Anakinra (ANA), an IL–1 receptor antagonist, in ALS patients. In a single arm pilot study we treated 17 ALS patients with ANA (100 mg) daily for one y...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Maier, André, Deigendesch, Nikolaus, Müller, Kathrin, Weishaupt, Jochen H., Krannich, Alexander, Röhle, Robert, Meissner, Felix, Molawi, Kaaweh, Münch, Christoph, Holm, Teresa, Meyer, Robert, Meyer, Thomas, Zychlinsky, Arturo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596620/
https://ncbi.nlm.nih.gov/pubmed/26444282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139684
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