Interleukin-1 Antagonist Anakinra in Amyotrophic Lateral Sclerosis—A Pilot Study

Preclinical studies show that blocking Interleukin–1 (IL–1) retards the progression of Amyotrophic Lateral Sclerosis (ALS). We assessed the safety of Anakinra (ANA), an IL–1 receptor antagonist, in ALS patients. In a single arm pilot study we treated 17 ALS patients with ANA (100 mg) daily for one y...

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Pubblicato in:PLoS One
Autori principali: Maier, André, Deigendesch, Nikolaus, Müller, Kathrin, Weishaupt, Jochen H., Krannich, Alexander, Röhle, Robert, Meissner, Felix, Molawi, Kaaweh, Münch, Christoph, Holm, Teresa, Meyer, Robert, Meyer, Thomas, Zychlinsky, Arturo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596620/
https://ncbi.nlm.nih.gov/pubmed/26444282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139684
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