The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells

17β-Estradiol (E2) exerts numerous beneficial effects in vascular disease. It regulates gene transcription through nuclear estrogen receptor α (ERα) via 2 activation functions, AF1 and AF2, and can also activate membrane ERα. The role of E2 on the endothelium relies on membrane ERα activation, but t...

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Vydáno v:Circ Res
Hlavní autoři: Smirnova, Natalia F., Fontaine, Coralie, Buscato, Mélissa, Lupieri, Adrien, Vinel, Alexia, Valera, Marie-Cécile, Guillaume, Maeva, Malet, Nicole, Foidart, Jean-Michel, Raymond-Letron, Isabelle, Lenfant, Francoise, Gourdy, Pierre, Katzenellenbogen, Benita S., Katzenellenbogen, John A., Laffargue, Muriel, Arnal, Jean-Francois
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2015
Témata:
Molecular Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596486/
https://ncbi.nlm.nih.gov/pubmed/26316608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.306416
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