Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia

BACKGROUND: Specific genes, such as BCAT1 and IKZF1, are methylated with high frequency in colorectal cancer (CRC) tissue compared to normal colon tissue specimens. Such DNA may leak into blood and be present as cell-free circulating DNA. We have evaluated the accuracy of a novel blood test for thes...

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Udgivet i:BMC Cancer
Main Authors: Pedersen, Susanne K., Symonds, Erin L., Baker, Rohan T., Murray, David H., McEvoy, Aidan, Van Doorn, Sascha C., Mundt, Marco W., Cole, Stephen R., Gopalsamy, Geetha, Mangira, Dileep, LaPointe, Lawrence C., Dekker, Evelien, Young, Graeme P.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596413/
https://ncbi.nlm.nih.gov/pubmed/26445409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1674-2
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