Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer

BACKGROUND: Differentially-methylated regions (DMRs) are characteristic of colorectal cancer (CRC) and some occur more frequently than common mutations. This study aimed to evaluate the clinical utility of assaying circulating cell-free DNA for methylation in BCAT1, IKZF1 and IRF4 for detection of C...

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Publicat a:Clin Epigenetics
Autors principals: Young, Graeme P., Symonds, Erin L., Nielsen, Hans Jørgen, Ferm, Linnea, Christensen, Ib J., Dekker, Evelien, van der Vlugt, Manon, Mallant-Hent, Rosalie C., Boulter, Nicky, Yu, Betty, Chan, Michelle, Tevz, Gregor, LaPointe, Lawrence C., Pedersen, Susanne K.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818774/
https://ncbi.nlm.nih.gov/pubmed/33478584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00999-y
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