HIV–tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

Patients with HIV-associated tuberculosis (TB) initiating antiretroviral therapy (ART) may develop immune reconstitution inflammatory syndrome (TB-IRIS). No biomarkers for TB-IRIS have been identified and the underlying mechanisms are unclear. Here we perform transcriptomic profiling of the blood sa...

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Udgivet i:Nat Commun
Main Authors: Lai, Rachel P. J., Meintjes, Graeme, Wilkinson, Katalin A., Graham, Christine M., Marais, Suzaan, Van der Plas, Helen, Deffur, Armin, Schutz, Charlotte, Bloom, Chloe, Munagala, Indira, Anguiano, Esperanza, Goliath, Rene, Maartens, Gary, Banchereau, Jacques, Chaussabel, Damien, O'Garra, Anne, Wilkinson, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595995/
https://ncbi.nlm.nih.gov/pubmed/26399326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9451
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