Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma: ATM, ATR and FA in lung carcinoma

BACKGROUND: ATM and ATR are kinases implicated in a myriad of DNA-damage responses. ATM kinase inhibition radiosensitizes cells and selectively kills cells with Fanconi anemia (FA) gene mutations. ATR kinase inhibition sensitizes cells to agents that induce replication stress and selectively kills c...

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Publicat a:BMC Cancer
Autors principals: Beumer, Jan H., Fu, Katherine Y., Anyang, Bean N., Siegfried, Jill M., Bakkenist, Christopher J.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595318/
https://ncbi.nlm.nih.gov/pubmed/26438152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1649-3
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