Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside of the crypt base stem cell niche

Hereditary mixed polyposis syndrome (HMPS) is characterised by the development of mixed morphology colorectal tumours and is caused by a 40 kb duplication that results in aberrant epithelial expression of the mesenchymal Bone Morphogenetic Protein antagonist, GREM1. Here we use HMPS tissue and a mou...

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Published in:Nat Med
Main Authors: Davis, Hayley, Irshad, Shazia, Bansal, Mukesh, Rafferty, Hannah, Boitsova, Tatjana, Bardella, Chiara, Jaeger, Emma, Lewis, Annabelle, Freeman-Mills, Luke, Giner, Francesc Castro, Rodenas-Cuadrado, Pedro, Mallappa, Sreelakshmi, Clark, Susan, Thomas, Huw, Jeffery, Rosemary, Poulsom, Richard, Rodriguez-Justo, Manuel, Novelli, Marco, Chetty, Runjan, Silver, Andrew, Sansom, Owen James, Greten, Florian R, Wang, Lai Mun, East, James Edward, Tomlinson, Ian, Leedham, Simon John
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594755/
https://ncbi.nlm.nih.gov/pubmed/25419707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3750
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