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Structural determinants of interaction, trafficking and function in the ClC-2/MLC1 subunit GlialCAM involved in leukodystrophy
Mutations in the genes encoding the astrocytic protein MLC1, the cell adhesion molecule GlialCAM or the Cl(−) channel ClC-2 underlie human leukodystrophies. GlialCAM binds to itself, to MLC1 and to ClC-2, and directs these proteins to cell–cell contacts. In addition, GlialCAM dramatically activates...
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| Veröffentlicht in: | J Physiol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley & Sons, Ltd
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4594291/ https://ncbi.nlm.nih.gov/pubmed/26033718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP270467 |
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