Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson’s disease

Microglia-mediated neuroinflammation may play an important role in the initiation and progression of dopaminergic (DA) neurodegeneration in Parkinson’s disease (PD), and toll-like receptor 4 (TLR4) is essential for the activation of microglia in the adult brain. However, it is still unclear whether...

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Vydáno v:Sci Rep
Hlavní autoři: Shin, Won-Ho, Jeon, Min-Tae, Leem, Eunju, Won, So-Yoon, Jeong, Kyoung Hoon, Park, Sang-Joon, McLean, Catriona, Lee, Sung Joong, Jin, Byung Kwan, Jung, Un Ju, Kim, Sang Ryoung
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594003/
https://ncbi.nlm.nih.gov/pubmed/26440368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14764
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